Episode 1 : Enough Nemesis to Go Around
Holmes returns to New York with a new apprentice and a renewed interest in working with the NYPD after being fired by London's MI6. However, Captain Gregson won't let him resume consulting for the department without permission from his former partner, Watson, the NYPD's new go-to private investigator. Gina Gershon and Ophelia Lovibond guest star.
Episode 2 : The Five Orange Pipz
When Holmes and Watson join forces on a double homicide, Sherlock's new apprentice, Kitty, threatens the investigation when she allows her jealousy of Sherlock and Joan's work rapport to override her better judgment.
Episode 3 : Just a Regular Irregular
Sherlock helps a math genius from his network of "Irregulars" experts after he stumbles upon a body while participating in a math puzzle competition. Meanwhile, Joan attempts to extend an olive branch after she learns about Kitty's past. NFL legend Phil Simms guest stars.
Episode 4 : Bella
When a groundbreaking artificial intelligence software program is stolen, Sherlock agrees to take on the case, but enlists Joan's assistance in solving it when he becomes more interested in disproving the computer's abilities than finding the thief. Meanwhile, Joan confronts Sherlock about his motives after she learns he has been in direct contact with her boyfriend, Andrew, without her knowledge.
Episode 5 : Rip Off
Sherlock and Kitty investigate the murder of a small postal store owner whose death is connected to the illegal diamond trade. Also, Captain Gregson puts his career in jeopardy when he hits a fellow NYPD officer.
Episode 6 : Terra Pericolosa
Holmes and Watson search for a thief who committed murder to steal a rare map. Meanwhile, Watson becomes concerned with Sherlock's escalating interference into Kitty's burgeoning personal life. Mamie Gummer guest stars.
Episode 7 : The Adventure of the Nutmeg Concoction
A bored Sherlock forces his investigative services onto Joan, who is trying to locate a woman who has been missing for five years, and the only clue is the smell of nutmeg at the site of her disappearance. Meanwhile, Joan?s bond with her long-distance boyfriend, Andrew, is tested when a man from her past reappears and asks for her help.
Episode 8 : End of Watch
Holmes and Watson join forces with the NYPD after a police officer is murdered. Also, Sherlock searches for the creator of a "recovery blog" who is posting personal statements he has made in sobriety meetings.
Episode 9 : The Eternity Injection
When a nurse Watson used to work with asks for her help finding their missing acquaintance, the woman's trail leads Watson and Holmes to another person who has disappeared. Also, Sherlock struggles with his sobriety when he finds the recovery process monotonous.
Episode 10 : Seed Money
While Kitty tries to find a runaway teen, Sherlock and Joan work a case in which the murder of a brilliant bioengineer looks to be at the hands of a drug cartel. Also, Joan makes a major life decision but worries it will impact Sherlock negatively, not knowing that Sherlock has big news of his own.
Episode 11 : The Illustrious Client
In the first episode of a two-part event, Watson begins her new job as an in-house investigator for an insurance firm. However, her attention shifts to a case that is personal for both her and Holmes when they join forces to eliminate an imminent threat to Kitty. Stuart Townsend guest stars.
Episode 12 : The One That Got Away
As Kitty begins to unravel due to the imminent threat to her safety, Sherlock and Joan intensify their efforts to help her. Also, the origin of Sherlock and Kitty's relationship is revealed. Stuart Townsend guest stars.
Episode 13 : Hemlock
When a debt collector is murdered, Holmes and Watson attempt to narrow down a suspect pool of thousands of consumers who owed the man money. Meanwhile, Watson's relationship with Andrew progresses when he asks her to meet his father for the first time.
Episode 14 : The Female of the Species
An unexpected event brings Watson into contact again with Elana March, the crime boss she brought to justice. Also, with Watson distracted, Holmes enlists Detective Bell to join him in a temporary partnership to solve a theft at a local zoo. Series star Lucy Liu directed the episode. Gina Gershon guest stars.
Episode 15 : When Your Number's Up
Holmes and Watson follow a blood trail into the world of wrongful death compensation when they investigate a series of murders in which the killer leaves envelopes of cash on the victims. Also, Holmes makes a generous gesture towards Watson as she suffers through the aftermath of a personal crisis. Alicia Witt guest stars.
Episode 16 : For All You Know
When Holmes is implicated in the murder of a woman who was killed during the height of his addiction, he investigates himself to find their connection. As Holmes retraces his steps with Watson's help, the clues make his confidence in his own character waver.
Episode 23 : Absconded
Holmes and Watson look into the death of a member of Holmes' online beekeeping community who was a researcher looking into a deadly Northeast honey bee outbreak. During the investigation, they meet Tara Parker, a brilliant entomologist, academic and the leader of New York's beekeeping society. Also, Captain Gregson enlists Watson's services in an off-book investigation that helps him make a life-changing decision. Sutton Foster guest stars.
Episode 24 : A Controlled Descent
When Holmes' former recovery sponsor and friend, Alfredo (Ato Essandoh), disappears, Holmes and Watson retrace his steps as Captain Gregson and Detective Bell lend NYPD's resources to help find him. As the group races to find him, Holmes wonders if his friend is a victim of foul play, or worse, if he has relapsed into addiction.