Episode 1 : Folie a Deux
When a serial bomber becomes active again after being dormant for six years, Watson seeks help from Shinwell Johnson (Nelsan Ellis), a former patient whose life she saved when she was a surgeon. Also, Holmes senses Watson is unhappy and questions whether she is still fulfilled by her detective career.
Episode 2 : Worth Several Cities
When the leader of a local street gang abducts Holmes to compel him to find the person responsible for a hit on his men, Holmes and Watson get caught in the middle of an international hunt to recover a centuries old, priceless artifact. Also, Watson debates whether a personal favor Shinwell asks of her is outside her comfort zone.
Episode 3 : Render, and Then Seize Her
Holmes learns a secret about Captain Gregson's girlfriend when she hires him for a case she wants kept off of Gregson's radar. Also, Holmes and Watson join the NYPD's search for an abducted woman.
Episode 4 : Henny Penny the Sky is Falling
Captain Gregson lobbies to include Holmes and Watson when his unit is selected to receive a city commendation for its exemplary work. Also, as Holmes and Watson consult on the investigation into a financial analyst?s murder, they are drawn into the world of asteroid research.
Episode 5 : To Catch a Predator Predator
Holmes and Watson have plenty of suspects when they investigate the murder of a man who led a secret life as a vigilante, "catfishing" sexual predators on dating sites and publicly shaming them. Also, when Shinwell's criminal record prevents him from finding a full-time job, Holmes disagrees with Watson?s plan to help him.
Episode 6 : Ill Tidings
Holmes and Watson investigate a mass murder when a chef and his patrons are poisoned after dining on a tasting menu tainted with snake venom. Also, Detective Bell's crush on a work colleague makes Holmes realize his and Fiona's (Betty Gilpin) relationship is at an important crossroads.
Episode 7 : Bang Bang Shoot Chute
Holmes and Watson search for two murderers after a base jumper is shot out of the sky by one killer, and has his parachute sabotaged by another. Also, after Joan?s sister, Lin (Samantha Quan), thinks she sees Shinwell with a member of his old gang, Joan takes drastic measures to make sure he won?t be drawn back into a life of crime.
Episode 8 : How the Sausage is Made
Joan worries Sherlock's sobriety is at risk when she learns he has been lying to her about attending recovery meetings. Also, Sherlock and Joan discover a man's death caused by ingesting poisoned sausage is connected to a lab working on a breakthrough in the artificial meat industry.
Episode 9 : It Serves You Right to Suffer
When Shinwell comes to Holmes and Watson for help after he's framed for a gang killing, they have three days to find the real murderer before he is arrested and sent back to jail.
Episode 10 : Pick Your Poison
When Watson is implicated in a DEA investigation into doctors writing illegal prescriptions, she and Holmes search for the person using her medical license to sell drugs.
Episode 11 : Be My Guest
Holmes and Watson race to find a woman who's been held captive for years before the kidnapper takes drastic steps to avoid being caught. Also, Watson becomes frustrated when Shinwell refuses to focus on his informant training with her and Holmes.
Episode 12 : Crowned Clown, Downtown Brown
When Holmes and Watson investigate a clown's murder upstate, they discover a connection between his death and the creation of a new weaponized virus. Also, Watson helps Bell when he's targeted by his new love interest Chantal's (Chasten Harmon) ex-husband in attempt to sabotage her career at the district attorney's office.
Episode 13 : Over a Barrel
A man takes hostages, including Joan, and threatens to execute them unless Holmes finds the person responsible for the death of his son. As Sherlock investigates, the captor gives him 16 hours to find the perpetrator before the statute of limitations on the crime runs out.
Episode 14 : Rekt in Real Life
Holmes and Watson investigate the murder of a former professional eSports video game player who died after being assaulted in front of his fans during a live video stream. Also, Shinwell approaches Joan for advice when his teenage daughter asks to meet with him for the first time in years.
Episode 15 : Wrong Side of the Road
Holmes' former protege, Kitty Winter (Ophelia Lovibond), returns to New York after a three-year absence to warn him that a killer is eliminating everyone involved with a case they worked on together in London, and they're the next targets. As Sherlock, Kitty, Joan and the NYPD join forces to find the perpetrator, Watson discovers Kitty has a life-changing secret.
Episode 21 : Fly into a Rage, Make a Bad Landing
When Detective Bell's girlfriend, Chantal (Chasten Harmon), is assaulted and her ex-husband is killed soon after, in what Holmes and Watson discover is a staged suicide, they search for one suspect behind the linked crimes. Also, as Bell fights the urge to seek his own brand of justice for Chantal, Sherlock makes a heartbreaking realization about the detective's past.
Episode 22 : Moving Targets
When a reality show contestant is murdered, Holmes and Watson zero in on another competitor as a suspect, a former war criminal who may be the most skilled killer they?ve ever pursued. Also, for the first time since he attacked Sherlock, Shinwell reaches out to Joan to ask for a favor.
Episode 23 : Scrambled
Holmes and Watson investigate a murder that puts them in the crosshairs of one of New York City's deadliest gangs. Also, Holmes' behavior becomes increasingly erratic when he secretly interacts with a mysterious woman.
Episode 24 : Hurt Me, Hurt You
Holmes and Watson pursue an elusive criminal as a gang war erupts in New York City. While the NYPD works to contain the violence, the two investigate the murder that appears to have ignited the city-wide conflict.